Duck β-defensin 10 inhibits Salmonella enterica by disrupting bacterial membrane integrity and its association with gut microbiota dynamics
Abstract
Salmonella infections pose a significant threat to waterfowl. Avian β-defensin 10 (AvBD10), a key molecule of host innate immunity, exhibits broad-spectrum antibacterial activity and immune regulatory function. However, research on the tissue-specific expression and antibacterial activity against Salmonella of AvBD10 in waterfowl remains limited. In this study, we first revealed the expression characteristics of AvBD10 in the tissues of ducks at different ages using in vivo experiments. Subsequently, we elucidated the interaction between AvBD10 and intestinal microorganisms, such as Salmonella, by combining 16S rDNA sequencing analysis of the microbiota in the cecum. Finally, we verified the antibacterial effect of AvBD10 on Salmonella using in vitro experiments. The results revealed that the expression of AvBD10 displayed notable (P
Fields of Study & Subjects
Antimicrobial Peptides and Activities
Invertebrate Immune Response Mechanisms
Pediatric health and respiratory diseases
Publication details
- Journal / source
- Poultry Science
- Publisher
- Elsevier BV
- Volume
- 105
- Issue
- 4
- Pages
- 106526–106526
- Publication date
- 28 January 2026
- Language
- EN