Management of moderate and severe ovarian hyperstimulation syndrome: a Canadian Fertility and Andrology Society clinical practice guideline

Reproductive BioMedicine Online 2026 Open access

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Authors: W. R. Buckett, Camille V Sylvestre, Kimberly E. Liu, NEAL G. MAHUTTE, Jason K. Min, Jeff Roberts, Julio Saumet, Heather Shapiro, Sony Sierra, Maria P Velez
DOI: 10.1016/j.rbmo.2026.105541
Cited by: 1
References: 64

Abstract

Ovarian hyperstimulation syndrome (OHSS) is a potentially serious complication associated with ovarian stimulation for assisted reproductive technology. While measures to prevent and reduce the incidence of OHSS are part of good clinical practice, OHSS still occurs, and patients may present to clinicians with varying familiarity with the condition. Diagnosis is largely clinical, although radiological and laboratory testing helps determine the severity of the syndrome. Management of moderate and severe OHSS is primarily supportive as either an outpatient or an inpatient and may include paracentesis. Critical OHSS needs hospitalization and multidisciplinary care. This clinical practice guideline assesses the published evidence regarding the diagnosis and management of patients presenting with moderate and severe OHSS.

Fields of Study & Subjects

Ovarian function and disorders Menopause: Health Impacts and Treatments Pituitary Gland Disorders and Treatments

Publication details

Journal / source
Reproductive BioMedicine Online
Publisher
Elsevier BV
Volume
52
Issue
6
Pages
105541–105541
Publication date
4 February 2026
Language
EN