S-nitrosylation of HINT1 in macrophages aggravates foam cell formation and atherosclerosis

Redox Biology 2026 Open access

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Authors: Ke Tang, Tianshu Zheng, Hao Zhu, Fan Xu, Congcong Ma, Zhenhua Qi, Siyi Cao, Qiang Da, Ke Yan, Wencheng Wu, Yi Han, Liping Xie
+2 more Yan Zhang, Yong Ji
DOI: 10.1016/j.redox.2026.104063
Cited by: 3
References: 46

Abstract

mice fed with high fat diet. Overall, SNO-HINT1 drives foam cell formation and atherosclerosis through reducing degradation of SR-A1 mediated by lysosome pathway and promoting CD36 transcription mediated by USF2. Our findings suggest that SNO-HINT1 can be a potential therapeutic target for atherosclerosis.

Fields of Study & Subjects

Cholesterol and Lipid Metabolism Nitric Oxide and Endothelin Effects Redox biology and oxidative stress

Publication details

Journal / source
Redox Biology
Publisher
Elsevier BV
Volume
90
Pages
104063–104063
Publication date
28 January 2026
Language
EN