The use of supplemental oxygen during cardiopulmonary resuscitation – a systematic review of the literature

Resuscitation Plus 2026 Open access

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Authors: Markus B. Skrifvars, S. D’Arrigo, S. Ohshimo, B. Grunau, T. Scquizzato, C. Crowley, J.C. Jakobsen, JJ. Petersen, CDB. Sillassen, CB. Kamp, GB. Madsen, PB. Andersen
+20 more VH. Niemelä, M. Makinen, IR. Drennan, A. Moskowitz, K. von Berg, J. Soar, Jerry Nolan, Asger Granfeldt, Anders Åneman, Keith Couper, Mathias Johan J Holmberg, Berndt Bottiger, BRIAN C. O’NEILL, Mike Parr, Peter Kudenchuk, Tonia Nicholson, Carolyn Zelop, Claudio Sandroni Michelle Welsford, Eric J. Lavonas, Chia Yew Woon
DOI: 10.1016/j.resplu.2026.101333
Cited by: 1
References: 25

Abstract

Purpose To evaluate whether the use of supplemental oxygen during cardiopulmonary resuscitation (CPR) improves outcomes after cardiac arrest. Methods We conducted a systematic review and registered the protocol PROSPERO (CRD420251243123). We searched 12 databases from inception to 27 October 2025 to identify studies evaluating supplemental oxygen use during CPR. Outcomes included return of spontaneous circulation (ROSC), survival, and survival with favorable neurological or functional outcome. Risk of bias was assessed using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool. Evidence was synthesized narratively without meta-analysis. Hyperoxaemia was defined as PaO 2 >300 mmHg (>40 kPa), normoxaemia as PaO 2 60–300 mmHg (8–40 kPa), and hypoxaemia as PaO 2

Fields of Study & Subjects

Cardiac Arrest and Resuscitation Respiratory Support and Mechanisms Airway Management and Intubation Techniques

Publication details

Journal / source
Resuscitation Plus
Publisher
Elsevier BV
Volume
29
Pages
101333–101333
Publication date
27 April 2026
Language
EN