EEG-guided early cessation of sedation and TTM in patients after cardiac arrest: a feasibility and safety study

Resuscitation 2026 Open access

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Authors: Marleen C. Tjepkema‐Cloostermans, Albertus Beishuizen, Aart C. Strang, Hanneke M. Keijzer, Johan A. Telleman, Simone P. Smook, J. Wytze Vermeijden, Jeannette Hofmeijer, Michel J.A.M. van Putten
DOI: 10.1016/j.resuscitation.2026.111101
Cited by: 3
References: 19

Abstract

OBJECTIVE: Despite substantial variability in the severity of post-anoxic encephalopathy, all comatose patients after cardiac arrest are usually treated according to the same standardised intensive care protocol, including sedation, mechanical ventilation, and targeted temperature management (TTM). We hypothesise that patients with a favourable EEG pattern (continuous EEG within 12 h after cardiac arrest) may not benefit from prolonged sedation and TTM. We studied the feasibility and safety of early cessation of sedation and TTM in this subgroup. METHODS: We conducted a non-randomised, controlled intervention study including 40 adult patients admitted to the ICU with postanoxic encephalopathy after cardiac arrest and an early (

Fields of Study & Subjects

Cardiac Arrest and Resuscitation Anesthesia and Sedative Agents Intensive Care Unit Cognitive Disorders

Publication details

Journal / source
Resuscitation
Publisher
Elsevier BV
Volume
225
Pages
111101–111101
Publication date
17 April 2026
Language
EN