The Thromboembolism Heparinization and AntithrombiN Observational Study (THANOS-1)

Research and Practice in Thrombosis and Haemostasis 2026 Open access

Read full text
Authors: Christiana K Prucnal, Grace Wang, Weixing Huang, Nora Horick, Ryan Mize, Isabel T. Dhar, Tyleah Brown, Sophie Flomenbaum, Kyle E. Chang, Timothy M. Matthews, Gregory A. Peters, Drew A. Birrenkott
+4 more Karsten Stannek, Eddie Eun Sang Lee, Sacha Uljon, Christopher Kabrhel
DOI: 10.1016/j.rpth.2026.103367
Cited by: 0
References: 20

Abstract

Background: Acute pulmonary embolism (PE) affects both hemodynamics and the clotting system, and changes in clotting protein activity may affect the effectiveness of anticoagulation. For example, PE may represent an acute, acquired antithrombin (AT)-deficient state, which may limit heparin effectiveness. However, the incidence and clinical effects of acquired AT deficiency after PE are not known. Objectives: Our primary aim was to calculate the proportion of patients with PE and acquired AT deficiency, defined a priori as

Fields of Study & Subjects

Venous Thromboembolism Diagnosis and Management Blood Coagulation and Thrombosis Mechanisms Heparin-Induced Thrombocytopenia and Thrombosis

Publication details

Journal / source
Research and Practice in Thrombosis and Haemostasis
Volume
10
Issue
1
Pages
103367–103367
Publication date
1 January 2026
Language
EN