The human induced pluripotent stem cell line CTGUi-002A was generated from a Perrault syndrome patient

Stem Cell Research 2026 Open access

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Authors: Shen-lin Wu, Yang Li, Tonghai Dou, Wei Wang, Jing-qiong Zhan, Ya-feng Lv
DOI: 10.1016/j.scr.2026.103929
Cited by: 0
References: 3

Abstract

We generated an induced pluripotent stem cell (iPSC) line, designated CTGUi002-A, from peripheral blood mononuclear cells (PBMCs) of a 9-year-old female with Perrault syndrome carrying biallelic TWNK mutations (c.811G>A and c.1163C>T), using Sendai virus-mediated delivery of OCT4, SOX2, KLF4, and c-MYC. The CTGUi002-A iPSC line retained the TWNK mutations and exhibited characteristic iPSC morphology, expressed pluripotency markers, maintained a normal karyotype, and demonstrated trilineage differentiation potential.

Fields of Study & Subjects

Pluripotent Stem Cells Research CRISPR and Genetic Engineering Mesenchymal stem cell research

Publication details

Journal / source
Stem Cell Research
Volume
92
Pages
103929–103929
Publication date
15 February 2026
Language
EN