Generation of two isogenic sickle cell disease induced pluripotent stem cell lines from ovarian fibroblasts

Stem Cell Research 2026 Open access

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Authors: Mitchell R. Harancher, Livianna K. Myklebust, Meena Sukhwani, Charvi Kanodia, Yi Sheng, Carlos A. Castro, Amanda C. Zielen, Kyle E. Orwig
DOI: 10.1016/j.scr.2026.103936
Cited by: 0
References: 6

Abstract

Curative bone marrow transplantation (BMT) therapies for sickle cell disease (SCD) can cause infertility. The Fertility Preservation Program (FPP) in Pittsburgh cryopreserves ovarian tissues for SCD patients prior to BMT in anticipation that these tissues can be used in the future to produce eggs and achieve a pregnancy. Here, we generated and validated two isogenic patient-derived induced pluripotent stem cell (iPSC) lines from ovarian cortex fibroblasts of a 28-year-old SCD patient.

Fields of Study & Subjects

Pluripotent Stem Cells Research Hematopoietic Stem Cell Transplantation Reproductive Biology and Fertility

Publication details

Journal / source
Stem Cell Research
Volume
92
Pages
103936–103936
Publication date
16 February 2026
Language
EN