Generation of a human induced pluripotent stem cell line NTUHi007-A from a patient with Parkinson’s disease harboring a heterozygous missense mutation c.1858 G > A (p.D620N) in VPS35 gene

Stem Cell Research 2026 Open access

Read full text
Authors: Ying‐Fa Chen, Chih‐Hsin Ou‐Yang, Chin‐Hsien Lin
DOI: 10.1016/j.scr.2026.103955
Cited by: 0
References: 3

Abstract

Vacuolar protein sorting 35 (VPS35) is a rare autosomal dominant cause of Parkinson's disease (PD), typically presenting with levodopa-responsive motor symptoms similar to idiopathic PD. Using a Sendai virus-based system, we generated an induced pluripotent stem cell line from peripheral blood mononuclear cells of a 48-year-old woman carrying a heterozygous VPS35 c.1858G > A (p.D620N) mutation. This cellular model provides a valuable tool for investigating pathogenic mechanisms and facilitating the development of potential PD therapies.

Fields of Study & Subjects

Pluripotent Stem Cells Research Parkinson's Disease Mechanisms and Treatments Nuclear Receptors and Signaling

Publication details

Journal / source
Stem Cell Research
Volume
93
Pages
103955–103955
Publication date
5 March 2026
Language
EN