Establishment of CSUASOi014-A, an induced pluripotent stem cell line from blood-derived cells of a Chinese patient carrying PRPF31 gene mutation

Stem Cell Research 2026 Open access

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Authors: Yuan Liang, Xihao Sun, Yuqin Liang, Hang Chen, Chunwen Duan, Yuexi Chen, Wenwei Li, Jianing Gu, Zekai Cui, Chengcheng Ding, Jiansu Chen
DOI: 10.1016/j.scr.2026.103965
Cited by: 0
References: 3

Abstract

Retinitis pigmentosa (RP) is a group of inherited retinal degenerative disorders characterized by progressive visual dysfunction. In this study, we generated an induced pluripotent stem cell (iPSC) line, CSUASOi014-A, from peripheral blood cells of a 40-year-old Chinese female patient clinically diagnosed with RP. Peripheral blood mononuclear cells were isolated and reprogrammed using an integration-free Sendai virus system. The established iPSC line harbors a heterozygous PRPF31 c.528-39_531del mutation. CSUASOi014-A provides a patient-specific cellular resource for studying the pathogenic mechanisms underlying PRPF31-associated RP.

Fields of Study & Subjects

Retinal Development and Disorders Pluripotent Stem Cells Research Retinal Diseases and Treatments

Publication details

Journal / source
Stem Cell Research
Volume
93
Pages
103965–103965
Publication date
16 March 2026
Language
EN