Generation of three hiPSC clones from a frontotemporal dementia (FTD) patient with a heterozygous MAPT mutation p.K298_H299insQ (c.896_897insACA)

Stem Cell Research 2026 Open access

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Authors: Takumi Hirose, Kei-ichi Ishikawa, Y. Li, Genko Oyama, Taku Hatano, Nobutaka Hattori, Wado Akamatsu
DOI: 10.1016/j.scr.2026.103980
Cited by: 1
References: 1

Abstract

A previously reported microtubule-associated protein tau (MAPT) mutation, p.K298_H299insQ, involving a glutamine insertion between lysine 298 and histidine 299, was identified in patients with frontotemporal dementia. We established induced pluripotent stem cell (iPSC) lines from a patient carrying this mutation. Generated iPSCs displayed typical pluripotency characteristics, differentiation potential into three germ layers, and stable karyotypes.

Fields of Study & Subjects

Amyotrophic Lateral Sclerosis Research Genomics and Rare Diseases Genetic Neurodegenerative Diseases

Publication details

Journal / source
Stem Cell Research
Publisher
Elsevier BV
Volume
93
Pages
103980–103980
Publication date
1 April 2026
Language
EN