Generation and characterization of fourteen induced pluripotent stem cell (iPSC) lines derived from endometrial stromal fibroblasts of women with polyendocrine metabolic ovarian syndrome (PMOS) (n = 7) and non-PMOS controls (n = 7)

Stem Cell Research 2026 Open access

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Authors: Masuma Khatun, Karolina Lundin, Riikka K. Arffman, Timo Tuuri, Andres Salumets, Terhi Piltonen, Juha S. Tapanainen
DOI: 10.1016/j.scr.2026.104079
Cited by: 1
References: 12

Abstract

Polyendocrine metabolic ovarian syndrome (PMOS) is a prevalent endocrine disorder with complex reproductive, metabolic, and psychological features. A total of fourteen induced pluripotent stem cell (iPSC) lines were generated from endometrial stromal fibroblasts using a CRISPRa-based reprogramming method, comprising seven iPSC lines obtained from women with PMOS (all three Rotterdam criteria) and seven from body mass index (BMI)-matched non-PMOS controls. This well-characterized resource provides a unique platform for investigating cell-intrinsic PMOS mechanisms, supporting targeted pathogenesis studies and translational advances.

Fields of Study & Subjects

Ovarian function and disorders Reproductive Biology and Fertility Reproductive System and Pregnancy

Publication details

Journal / source
Stem Cell Research
Publisher
Elsevier BV
Volume
95
Pages
104079–104079
Publication date
13 August 2026
Language
EN