Secondary hemophagocytic lymphohistiocytosis concurrent with febrile infection-related epilepsy syndrome in a child

Seizure 2026 Open access

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Authors: Oi‐Wa Chan, Chun‐Nun Chao, Shao‐Hsuan Hsia, En‐Pei Lee, Kuang-Lin Lin, Jainn‐Jim Lin
DOI: 10.1016/j.seizure.2026.01.015
Cited by: 0
References: 4

Abstract

Febrile infection-related epilepsy syndrome (FIRES) is a rare and devastating epileptic encephalopathy that affects previously healthy children and adults. It presents with new-onset refractory status epilepticus and encephalopathy within 24 hours to two weeks following a febrile illness [1]. FIRES is now considered a subcategory of new-onset refractory status epilepticus (NORSE) [1]. Although the precise pathogenesis remains unclear, dysregulated innate immunity appears to play a central role [2].

Fields of Study & Subjects

Autoimmune and Inflammatory Disorders Research Epilepsy research and treatment Infectious Encephalopathies and Encephalitis

Publication details

Journal / source
Seizure
Volume
136
Pages
1–3
Publication date
29 January 2026
Language
EN