Outcomes of Left Atrial Appendage Occlusion in Patients With Cardiac Amyloidosis

Structural Heart 2026 Open access

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Authors: Sonia Kshatri, David Lewandowski, Jake Luo, Mohammad Assadi Shalmani, Marcie G. Berger, Garg Jalaj, Divyanshu Mohananey
DOI: 10.1016/j.shj.2026.100795
Cited by: 0
References: 1

Abstract

• Patients with cardiac amyloidosis (CA) and atrial fibrillation are at high risk for thrombo-embolic as well as bleeding complications. However, there is a paucity of data for left atrial appendage occlusion in these patients. • We found that while there was no significant difference in overall composite primary outcome (death, stroke, transient ischemic attack and thromboembolic events) between patients with and without CA; those with CA had outcomes similar to patients without CA with intermediate to high CHA 2 DS 2 -VASc scores. • A propensity matched analysis similarly revealed significantly worse outcomes in patients with CA.

Fields of Study & Subjects

Atrial Fibrillation Management and Outcomes Amyloidosis: Diagnosis Treatment Outcomes Cardiac tumors and thrombi

Publication details

Journal / source
Structural Heart
Volume
10
Issue
4
Pages
100795–100795
Publication date
15 January 2026
Language
EN