Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration

Cell stem cell 2026 Open access

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Authors: Nathalie G. Saurat, Andrew P. Minotti, Maliha T. Rahman, Trisha Sikder, Chao Zhang, Daniela Cornacchia, Johannes Jungverdorben, Gabriele Ciceri, Doron Betel, Lorenz Studer
DOI: 10.1016/j.stem.2025.12.019
Cited by: 1

Abstract

concentration of SB431542 as 10 mM instead of 10 μM in the dopamine neuron differentiation section of the Method details section.We apologize for this error, which has been corrected in the original version.The corrected manuscript also includes additional changes to comply with the open access policy requirements of the funder (Aligning Science Across Parkinson's disease).These include more detailed information listed in the key resource table, links to detailed protocols and code used in the study, and access to source data for all figures and supplemental information (which was added as Data S1 in the supplemental files).None of the changes made in this correction affect the conclusions of the manuscript.

Fields of Study & Subjects

Genetic Neurodegenerative Diseases Amyotrophic Lateral Sclerosis Research Alzheimer's disease research and treatments

Publication details

Journal / source
Cell stem cell
Publisher
Elsevier BV
Volume
33
Issue
2
Pages
355–359
Publication date
3 January 2026
Language
EN