Adult neurogenesis: New neurons, new opportunities

Cell stem cell 2026 Open access

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Authors: Birte Doludda, Warsha Barde, Francesco D’Egidio, Carlos P. Fitzsimons, Jonas Frisén, Fred H. Gage, Sebastian Jessberger, Orly Lazarov, D. Chichung Lie, Paul J. Lucassen, Chiara de Lucia, Evgenia Salta
+5 more Hongjun Song, Juan Song, Sandrine Thuret, Tomohisa Toda, Gerd Kempermann
DOI: 10.1016/j.stem.2026.01.014
Cited by: 7
References: 102

Abstract

The 38 currently registered clinical trials with the keyword "adult neurogenesis" indicate growing interest in new neurons as a target for intervention. Today, we have strong evidence that adult neurogenesis is involved in hippocampal function and can contribute to brain functions in health and disease. Neurogenesis research can now ask new questions, such as (1) the identity of stem cells and their input integration for initiating neurogenesis, (2) the nature of the neurogenic niche and neurogenesis without stem cell activity, (3) the complex functionality beyond the hippocampus, and (4) evolutionary and computational theory, including neurogenic neural networks for artificial intelligence.

Fields of Study & Subjects

Neurogenesis and neuroplasticity mechanisms Anesthesia and Neurotoxicity Research Planarian Biology and Electrostimulation

Publication details

Journal / source
Cell stem cell
Publisher
Elsevier BV
Volume
33
Issue
3
Pages
382–392
Publication date
1 March 2026
Language
EN