What we thought we knew about TNF—And what we now must re-learn
Abstract
Tumor necrosis factor (TNF) was long cast as a hematopoiesis villain, driving bone marrow and hematopoietic stem cell (HSC) suppression. We now see that TNF's effects are cell type-, context-, and time-dependent. Rather than being simply "bad," TNF can prune progenitors while transiently reprogramming HSCs without sacrificing long-term regenerative capacity.
Fields of Study & Subjects
Immunotoxicology and immune responses
Neurology and Historical Studies
Animal testing and alternatives
Publication details
- Journal / source
- Stem Cell Reports
- Publisher
- Elsevier BV
- Volume
- 21
- Issue
- 3
- Pages
- 102827–102827
- Publication date
- 26 February 2026
- Language
- EN