OsFTIP6 modulates cadmium accumulation and tolerance in rice

ABSTRACT Cadmium (Cd) is recognized as a toxic heavy metal that exerts detrimental effects on animals, plants, the environment, and human well-being. Deepening our understanding of the mechanisms by which Cd triggers responses in rice is crucial to develop strategies to reduce Cd uptake. While several transporters have been identified, the complex process of Cd transport and accumulation in rice still requires further investigation. In the present investigation, we highlight the role of OsFTIP6, which is notably induced under Cd stress. We observed that the Osftip6 mutant is more susceptible to Cd stress. The loss function of OsFTIP6 reduces Cd resistance by promoting Cd accumulation and movement, disrupting chlorophyll production, inhibiting antioxidant enzymes, and increasing reactive oxygen species (ROS) in rice. Moreover, OsFTIP6 modulates the effects of Cd toxicity on rice seedlings by affecting the expression of genes associated with Cd transport and ROS scavenging. This study provides evidence that OsFTIP6 modulates Cd accumulation and tolerance in rice. Our findings also offer a valuable genetic target for combating Cd stress in rice.