Where you start could determine where you end up
Abstract
A significant subset of the eukaryotic proteome must localize to multiple cellular compartments, necessitating the emergence of mechanisms to produce protein isoforms with distinct targeting sequences. Ly et al. reveal that alternative start-codon selection during translation initiation is a pervasive mechanism for dual localization of proteins by generating N-terminal isoforms.
Fields of Study & Subjects
RNA and protein synthesis mechanisms
Machine Learning in Bioinformatics
Antimicrobial Peptides and Activities
Publication details
- Journal / source
- Trends in Cell Biology
- Volume
- 36
- Issue
- 2
- Pages
- 83–85
- Publication date
- 8 January 2026
- Language
- EN