Ferroptosis as an approach to leverage cancer metabolism
Abstract
Ferroptosis is a cell death process defined by the iron-mediated peroxidation of membrane phospholipids that overwhelms the cell's innate antioxidant capabilities. Sitting at the nexus of iron, lipid, reactive oxygen species stress responses, and cellular metabolism, ferroptosis is intricately tied to these pathways. The burgeoning field of cancer metabolism has revealed that cancer cells exhibit changes in ferroptosis-relevant metabolic pathways, thereby opening an important avenue of investigation into whether tumors can have characteristic metabolic alterations that render them exquisitely sensitive to ferroptotic cell death. In this review, we highlight recent findings in the metabolic pathways linking ferroptosis and oncogenesis, as well as implications for future cancer therapeutic strategies.
Fields of Study & Subjects
Ferroptosis and cancer prognosis
Cancer
Lipids
and Metabolism
Clusterin in disease pathology
Publication details
- Journal / source
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Volume
- 36
- Issue
- 7
- Pages
- 545–560
- Publication date
- 9 April 2026
- Language
- EN