Brazilian Registry of Thrombotic Thrombocytopenic Purpura: A prospective cohort study of diagnosis, management and outcomes in Brazil

Thrombosis Research 2026 Open access

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Authors: Thaís D.R. Nóbrega, Tiago Boechat, Denys Eiti Fujimoto, Síbia Soraya Marcondes, Silvia Bueno, Suzanna A. Tavares, A. Prezotti, Juliana S.M. Duarte, Fabiana C.C. Piassi, Lucas Cesped, Erica Okazaki, Bianca Stefanello
+3 more Carolina Costa-Lima, Paula R. Villaça, Fernanda A. Orsi
DOI: 10.1016/j.thromres.2026.109590
Cited by: 1
References: 33

Abstract

Most data supporting current knowledge about thrombotic thrombocytopenic purpura (TTP) come from high-income regions, while little is known about treatment access and prognosis in low- and middle-income countries. To address this gap, we conducted a multicenter prospective study that included 85 TTP patients in Brazil between 2018 and 2024, with a 12-month follow-up. The median age was 37 years (IQR 27-45) and 76% were female. The median PLASMIC score was six (IQR 6.0-7.0), and ADAMTS13 activity was tested in 62.4% of patients (all

Fields of Study & Subjects

Complement system in diseases Blood groups and transfusion Hemophilia Treatment and Research

Publication details

Journal / source
Thrombosis Research
Publisher
Elsevier BV
Volume
258
Pages
109590–109590
Publication date
15 January 2026
Language
EN