Principles for the design of multispecific proteins

Trends in Biochemical Sciences 2026 Open access

Read full text
Authors: Shankar Raj Devkota, Pramod Aryal, Mikaela Bell, Surendra Kunwar, Martin J. Stone, Ram Prasad Bhusal
DOI: 10.1016/j.tibs.2026.04.007
Cited by: 1
References: 14

Abstract

Multispecificity involves high-affinity binding to multiple related ligands while preserving discrimination against other ligands. The binding of tick evasins to human CC chemokines exemplifies key principles of multispecific binding: a rigid core recognising conserved features of all targets, with flexible peripheral regions enabling discrimination within the target family.

Fields of Study & Subjects

Chemokine receptors and signaling Monoclonal and Polyclonal Antibodies Research vaccines and immunoinformatics approaches

Publication details

Journal / source
Trends in Biochemical Sciences
Publisher
Elsevier BV
Volume
51
Issue
6
Pages
538–541
Publication date
2 May 2026
Language
EN