RNA polymerase II: the elephant in the room
Abstract
How genes respond to external signals is poorly understood, with transcription factors and histones proposed as mediators of signals to RNA polymerase II (Pol II). However, recent work shows that Pol II is the direct target of more than 100 protein kinases, a previously underappreciated mechanism for generating epigenetic complexity.
Fields of Study & Subjects
Genomics and Chromatin Dynamics
Epigenetics and DNA Methylation
Bacterial Genetics and Biotechnology
Publication details
- Journal / source
- Trends in Genetics
- Publisher
- Elsevier BV
- Volume
- 42
- Issue
- 4
- Pages
- 311–313
- Publication date
- 11 March 2026
- Language
- EN