Dopamine’s secret agent: serotonin
Abstract
Abstract Dopamine suppresses GABA release from striatal terminals in the substantia nigra pars reticulata. Molinari et al. recently demonstrated that this suppression is frequency-dependent—instituting a high-pass filter on striatal ‘direct pathway' transmission—and does not require dopamine receptors. Rather, dopamine upregulates serotonin, activating presynaptic 5HT1B receptors to exert its effects.
Fields of Study & Subjects
Neurotransmitter Receptor Influence on Behavior
Neuroscience and Neuropharmacology Research
Neural dynamics and brain function
Publication details
- Journal / source
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Volume
- 49
- Issue
- 2
- Pages
- 77–79
- Publication date
- 1 February 2026
- Language
- EN