Micro- and nanoplastics in neurological dysfunction
Abstract
Plastic particles can interfere with the nervous system and are increasingly recognised as a global health concern. This review encompasses recent findings on the impact of plastic particles on brain health, including studies in humans, rodents, nematodes, and zebrafish. We discuss how plastics can impact cellular metabolism, affect developmental brain processes, and increase vulnerability to neurodevelopmental disorders and depression. Additionally, we review the potential of plastic particles to interact with the immune system and trigger pathological protein aggregation, enhancing susceptibility to neurodegeneration. Finally, we evaluate knowledge gaps that should be addressed to better understand the long-term impacts of plastic particles on the nervous system and neurological disorders.
Fields of Study & Subjects
Microplastics and Plastic Pollution
Facial Rejuvenation and Surgery Techniques
Nanocomposite Films for Food Packaging
Publication details
- Journal / source
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Volume
- 49
- Issue
- 3
- Pages
- 185–197
- Publication date
- 25 February 2026
- Language
- EN