Cerebral haemodynamics and white matter hyperintensities: findings using non-invasive brain imaging

The Journal of Prevention of Alzheimer s Disease 2026 Open access

Read full text
Authors: Ashwati Vipin, James Xiao Yuan Chen, Mervin Tee, Saima Hilal, Yi Jin Leow, Simon Konstandin, Klaus Eickel, Matthias Günther, Jan Petr, Henk J. M. M. Mutsaerts, Nagaendran Kandiah
DOI: 10.1016/j.tjpad.2026.100479
Cited by: 0
References: 43

Abstract

Background: Utilizing non-invasive neuroimaging for characterization of blood brain barrier (BBB) changes and perfusion deficits underlying SVD pathobiology including white matter hyperintensities (WMH) remains largely unexplored. We examined the underlying haemodynamics of WMH by assessing complex relationships between blood flow, BBB permeability and WMH burden.

Fields of Study & Subjects

Cerebrovascular and genetic disorders Advanced MRI Techniques and Applications Barrier Structure and Function Studies

Publication details

Journal / source
The Journal of Prevention of Alzheimer s Disease
Volume
13
Issue
3
Pages
100479–100479
Publication date
19 January 2026
Language
EN