Association of cardiac biomarkers with longitudinal cognitive changes in the general population

The Journal of Prevention of Alzheimer s Disease 2026 Open access

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Authors: Fang-Fei Wei, Dubo Chen, Chaoxin Xu, Zhongping Yu, Zihao Chen, Chang Chen, Xin He, JingJing Zhao, Wenqing Li, Cuiping Zhao, Jiangui He, Yugang Dong
+2 more Jan A. Staessen, Chen Liu
DOI: 10.1016/j.tjpad.2026.100494
Cited by: 1
References: 36

Abstract

BACKGROUND: Little is known about the association of high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) with changes in cognitive performance over time. OBJECTIVES: To investigate the association of cardiac biomarkers with cognitive changes over time. PARTICIPANTS: The study population consisted of 2540 stroke-free participants (56.1 % women; 21.2 % Black; mean age, 74.5 years) enrolled in the Atherosclerosis Risk in Communities study. MEASUREMENTS: Associations of the changes in the Mini Mental State Examination (MMSE) scores with the log-transformed cardiac biomarkers were modelled using multivariable linear and restricted cubic spline regression. RESULTS: Over 6.6 years (median), the MMSE score decreased by 0.57 (95 % CI, 0.46-0.67) and the frequency of an MMSE score

Fields of Study & Subjects

Dementia and Cognitive Impairment Research GDF15 and Related Biomarkers Heart Failure Treatment and Management

Publication details

Journal / source
The Journal of Prevention of Alzheimer s Disease
Publisher
Elsevier BV
Volume
13
Issue
4
Pages
100494–100494
Publication date
30 January 2026
Language
EN