Nociceptive neuroimmune circuit drives immune evasion
Abstract
Tumor-associated sensory nerves are emerging regulators of cancer immunity, yet their role in systemic immunosuppression remains unclear. Zhang et al. revealed that tumors hijack an interorgan nociceptor-slit guidance ligand 2-calcitonin gene-related peptide circuit to escape immune surveillance. Disrupting this neural loop restores T-cell function and enhances immunotherapy efficacy.
Fields of Study & Subjects
Vagus Nerve Stimulation Research
T-cell and B-cell Immunology
Neuroinflammation and Neurodegeneration Mechanisms
Publication details
- Journal / source
- Trends in cancer
- Publisher
- Elsevier BV
- Volume
- 12
- Issue
- 3
- Pages
- 212–214
- Publication date
- 1 March 2026
- Language
- EN