The rationale for targeting nectin-4 in pancreatic cancer
Abstract
Nectin-4 is an immunoglobulinlike cell adhesion molecule that contributes to tumor aggressiveness and immune evasion in pancreatic ductal adenocarcinoma (PDAC). Its high and selective expression on pancreatic cancer cells, together with the clinical efficacy of nectin-4-targeted antibody-drug conjugates in other solid tumors, establishes nectin-4 as a compelling therapeutic target in PDAC.
Fields of Study & Subjects
Pancreatic and Hepatic Oncology Research
Cancer Immunotherapy and Biomarkers
Monoclonal and Polyclonal Antibodies Research
Publication details
- Journal / source
- Trends in cancer
- Volume
- 12
- Issue
- 6
- Pages
- 481–484
- Publication date
- 10 March 2026
- Language
- EN