β-catenin at the crossroads of cancer and neurodevelopment

Trends in cancer 2026 Open access

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Authors: Caroline E. Nunes‐Xavier, Ana Rodríguez-Ramos, Rafael Pulido
DOI: 10.1016/j.trecan.2026.05.001
Cited by: 1
References: 15

Abstract

The essential role of β-catenin/CTNNB1 in cell development highlights its therapeutic potential in cancer and neurodevelopmental syndromes. Opposing functional alterations of β-catenin in these diseases reflect distinct pathogenic genetic events in CTNNB1, leading to antagonistic therapeutic approaches. A comprehensive understanding of β-catenin functions in physiology and pathology will facilitate the implementation of β-catenin/CTNNB1-based therapies.

Fields of Study & Subjects

Wnt/β-catenin signaling in development and cancer HER2/EGFR in Cancer Research TGF-β signaling in diseases

Publication details

Journal / source
Trends in cancer
Publisher
Elsevier BV
Volume
12
Issue
7
Pages
580–583
Publication date
30 May 2026
Language
EN