Oral interferon alpha treatment significantly reduces halitosis and Porphyromonas gulae growth in dogs with periodontal disease
Abstract
Periodontal disease (PD) is a multifactorial disease accompanied by attachment loss, resulting in tooth loss, and among the most prevalent infectious diseases in dogs. This study aimed to examine the therapeutic effects of canine interferon (INF)-α by focusing on anti-bacterial and -halitosis effects in dogs with PD. A clinical study in 32 dogs with PD was performed by one-month (every three or four days, twice weekly) oral treatment with 1 × 103 LU of canine INF-α. Our findings indicate that oral canine INF-α treatment significantly decreases the concentrations of methyl mercaptan, Porphyromonas gulae activity, and DNA detection.
Fields of Study & Subjects
Oral microbiology and periodontitis research
Dental Research and COVID-19
Veterinary Medicine and Surgery
Publication details
- Journal / source
- The Veterinary Journal
- Volume
- 317
- Pages
- 106613–106613
- Publication date
- 24 February 2026
- Language
- EN