Predicting thorough QT safety profile using hERG IC10 versus IC50

Journal of Pharmacological and Toxicological Methods 2026 Open access

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Authors: Andrew G. Edwards, William Crumb
DOI: 10.1016/j.vascn.2026.108564
Cited by: 1
References: 39

Abstract

provides a direct index of QT liability, which takes advantage of differences in Hill slope to improve prediction of ΔΔQTc liabilities near critical hERG inhibition of ∼10%.

Fields of Study & Subjects

Cardiac electrophysiology and arrhythmias ECG Monitoring and Analysis Cardiac pacing and defibrillation studies

Publication details

Journal / source
Journal of Pharmacological and Toxicological Methods
Publisher
Elsevier BV
Volume
140
Pages
108564–108564
Publication date
20 July 2026
Language
EN