Assessing Barriers and Improving Compliance with Penicillin De-labeling Following Negative Allergy Testing: A Quality Improvement Initiative

World Allergy Organization Journal 2026 Open access

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Authors: Sherin Rahim Thalappil, Dalal Sideeg Abass Mudawi, Asaad Omer Imameldin, Sara Saeed Ibrahim Mohamed, Hassan Mobayedh, Maryam Ali Al‐Nesf, Salma Taha
DOI: 10.1016/j.waojou.2026.101256
Cited by: 0

Abstract

Penicillin allergy is the most reported drug allergy, yet up to 90% of labeled individuals are not truly allergic. Persisting labels after negative testing contribute to unnecessary avoidance, broader-spectrum antibiotic use, and impaired antimicrobial stewardship. This quality improvement (QI) initiative sought to increase compliance with penicillin allergy de-labeling in patients with negative allergy testing in our tertiary Allergy Clinic from a baseline of 62% to 90% by June 2024.

Fields of Study & Subjects

Drug-Induced Adverse Reactions Antibiotic Use and Resistance Pharmacovigilance and Adverse Drug Reactions

Publication details

Journal / source
World Allergy Organization Journal
Volume
19
Issue
2
Pages
101256–101256
Publication date
1 February 2026
Language
EN