A Novel Variant of CORO1A Gene Contributing to The Development of Primary Immunodeficiency in Children

World Allergy Organization Journal 2026 Open access

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Authors: Alanoud Aljohani, Yazeed Alayed, Khalid Alshaygi, Mofareh AlZahrani, Hamza Alghamdi
DOI: 10.1016/j.waojou.2026.101258
Cited by: 1

Abstract

The case report describes a novel finding of a homozygous variant in the CORO1A gene, associated with severe combined immunodeficiency (SCID), in a 9-year-old female patient with recurrent infections and unique immunological features, including T-cell lymphocytosis and B-cell lymphopenia.

Fields of Study & Subjects

Immunodeficiency and Autoimmune Disorders T-cell and B-cell Immunology Blood disorders and treatments

Publication details

Journal / source
World Allergy Organization Journal
Publisher
Elsevier BV
Volume
19
Issue
2
Pages
101258–101258
Publication date
1 February 2026
Language
EN