Beyond the Butterfly Rash: The Complex Web of Systemic Lupus and Its Comorbidities

World Allergy Organization Journal 2026 Open access

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Authors: Asmaa Abubaker, Samar AlEmadi, Yasmin Elkhatib, Dana Deyab, Miral Hamed, Fatemeh Bagherizadeh, Fares Al‐Ejeh, Houari Abdesselem, Maryam Ali Al‐Nesf
DOI: 10.1016/j.waojou.2026.101262
Cited by: 0

Abstract

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with diverse manifestations that can affect nearly every organ system. The symptoms range from mild skin or joint involvement to severe, life-threatening complications. In clinical practice, patients often present with an intricate overlap of autoimmune, allergic, endocrine, and hematologic comorbidities, each reflecting an underlying immune system imbalance. These interconnected conditions blur diagnostic boundaries, heighten disease complexity, and add to the daily challenges in management.

Fields of Study & Subjects

Systemic Lupus Erythematosus Research Systemic Sclerosis and Related Diseases Vasculitis and related conditions

Publication details

Journal / source
World Allergy Organization Journal
Volume
19
Issue
2
Pages
101262–101262
Publication date
1 February 2026
Language
EN