A familial form of Atypical Hemolytic Uremic Syndrome associated with CD46 deficiency

World Allergy Organization Journal 2026 Open access

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Authors: Sihem Taguemount, Azzeddine Tahiat, Nadia Chaouchi, Kamel Djenouhat
DOI: 10.1016/j.waojou.2026.101275
Cited by: 0

Abstract

Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy defined by the association of mechanical hemolytic anemia, consumptive thrombocytopenia and acute renal failure secondary to dysregulation of the alternative complement pathway. Mutations in the genes of CFH, CFI and CD46 have been reported in 30%, 15%, and 10% respectively. This report describes, for the first time, a familial case of aHUS associated with CD46 deficiency.

Fields of Study & Subjects

Complement system in diseases Coagulation Bradykinin Polyphosphates and Angioedema Renal Diseases and Glomerulopathies

Publication details

Journal / source
World Allergy Organization Journal
Volume
19
Issue
2
Pages
101275–101275
Publication date
1 February 2026
Language
EN