Interest of Anti-HK1 and Anti-KELCH12 Autoantibodies as New Markers in the Diagnosis of Primary Biliary Cholangitis
Abstract
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by the presence of specific autoantibodies. The antimitochondrial antibody type M2 (AMA-M2) is the main serological marker, but its absence in some patients justifies the search for other autoantibodies. This study aims to evaluate the relevance of anti-HK1 and anti-KELCH12 autoantibodies as new markers for the serological diagnosis of PBC. A search for anti-HK1 and anti-KELCH12 autoantibodies was conducted using ELISA in 55 patients with PBC and 25 healthy controls.
Fields of Study & Subjects
Liver Diseases and Immunity
Pediatric Hepatobiliary Diseases and Treatments
IgG4-Related and Inflammatory Diseases
Publication details
- Journal / source
- World Allergy Organization Journal
- Volume
- 19
- Issue
- 2
- Pages
- 101276–101276
- Publication date
- 1 February 2026
- Language
- EN