Clinical, Immunological and Genetic Features of STAT3-HIES Patients: A Multisystemic and Heterogeneous Presentation

World Allergy Organization Journal 2026 Open access

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Authors: Rania Lasry, I. Benhssain, Ahmed Aziz Bousfiha, Fatima Ailal
DOI: 10.1016/j.waojou.2026.101283
Cited by: 0

Abstract

The hyper-IgE syndrome is a rare disorder of immunity and connective tissue characterized by a complex phenotype (elevated serum IgE levels, boils, cyst-forming pneumonias, retained primary dentition, and bone abnormalities.).While the infectious manifestations are well-known, the allergic features such as severe eczema, food allergies, and asthma, are often underrecognized.

Fields of Study & Subjects

Immunodeficiency and Autoimmune Disorders Autoimmune and Inflammatory Disorders Research Cytokine Signaling Pathways and Interactions

Publication details

Journal / source
World Allergy Organization Journal
Volume
19
Issue
2
Pages
101283–101283
Publication date
1 February 2026
Language
EN