A case series of three brothers with combined Immunodeficiency: shared genetics and immune dysregulation behind distinct phenotypes

World Allergy Organization Journal 2026 Open access

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Authors: Mohammad Nabavi, Sima Shokri, M H Bemanian, Morteza Fallahpour, Saman Tavakoli, Seyedehshabnam Seyedsalehi
DOI: 10.1016/j.waojou.2026.101292
Cited by: 0

Abstract

Combined immunodeficiency (CID) represents a group of genetic immunodeficiencies affecting both cellular and humoral immune responses. We present a rare familial case series of three brothers, aged 32, 27, and 23 years respectively, with CID and immune dysregulation as common leading features, but holding distinct multi-organ involvement phenotypes.

Fields of Study & Subjects

Immunodeficiency and Autoimmune Disorders Blood disorders and treatments T-cell and B-cell Immunology

Publication details

Journal / source
World Allergy Organization Journal
Volume
19
Issue
2
Pages
101292–101292
Publication date
1 February 2026
Language
EN