Case report of two new patients with ZNF341 deficiency in Iran
Abstract
The ZNF341 gene provides instructions for making a transcription factor, which is a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes. The ZNF341 protein is thought to regulate the activity of the STAT1 and STAT3 genes, controlling production of the STAT1 and STAT3 proteins, respectively. Both proteins are involved in the immune system. They control pathways in cells that help fight foreign invaders such as viruses, bacteria, and fungi. The STAT3 protein, in particular, transmits signals for the maturation of immune system cells, especially T cells and B cells.
Fields of Study & Subjects
Immunodeficiency and Autoimmune Disorders
Cytokine Signaling Pathways and Interactions
T-cell and B-cell Immunology
Publication details
- Journal / source
- World Allergy Organization Journal
- Volume
- 19
- Issue
- 2
- Pages
- 101296–101296
- Publication date
- 1 February 2026
- Language
- EN