F12 Variant–Related Hereditary Angioedema with Normal C1 Inhibitor : Three Cases from a Moroccan Family

World Allergy Organization Journal 2026 Open access

Read full text
Authors: H. KALIL, Chaymae Oujane, K. MOUSSAYER, A.A. Bousfiha, J. ELBAKKOURI
DOI: 10.1016/j.waojou.2026.101305
Cited by: 0

Abstract

Hereditary angioedema with normal C1 inhibitor (HAE-nC1INH) is a rare autosomal dominant disorder mediated by bradykinin. Mutations in the F12 gene, encoding coagulation factor XII, are a major cause of this condition (formerly type III HAE). It is characterized by skin swellings, abdominal pain, and the risk of asphyxiation from upper airway obstruction. HAE-nC1INH has also been associated with variants in ANGPT1, PLG, KNG1, MYOF, and HS3ST6. In Morocco, HAE remains underdiagnosed, partly due to immunogenetic diversity.

Fields of Study & Subjects

Coagulation Bradykinin Polyphosphates and Angioedema Complement system in diseases Pineapple and bromelain studies

Publication details

Journal / source
World Allergy Organization Journal
Volume
19
Issue
2
Pages
101305–101305
Publication date
1 February 2026
Language
EN