Evaluation of Serum IL-35 Level in Patients with Chronic Spontaneous Urticaria: A case control study

World Allergy Organization Journal 2026 Open access

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Authors: Maryam Khoshkhui, Melika Zarei Sani, Sajad Dehnavi, Mojgan Mohammadi, Farahzad Jabbari Azad
DOI: 10.1016/j.waojou.2026.101307
Cited by: 0

Abstract

Chronic spontaneous urticarial (CSU) is a common disorder characterized by pruritic swelling and/or angioedema lasting more than six weeks. Autoimmune mechanisms are involved in the pathogenesis of CSU. Interleukin (IL)-35 is a regulatory T (Treg) cell-derived cytokine associated with suppression of helper T (Th) cells subsets that modulate Th1/Th2 and Th17/Treg balances; and is decreased in autoimmune conditions. The present study investigated serum IL-35 levels in CSU patients compared to healthy controls.

Fields of Study & Subjects

Urticaria and Related Conditions Mast cells and histamine Dermatology and Skin Diseases

Publication details

Journal / source
World Allergy Organization Journal
Volume
19
Issue
2
Pages
101307–101307
Publication date
1 February 2026
Language
EN