Targeting Metabolic and Inflammatory Crosstalk: Efficacy of a Triple Combination Therapy Modulating Glycolysis, Autophagy, and Pro-inflammatory Signaling in Suppressing Oral Squamous Cell Carcinoma Progression and Metastasis"

World Allergy Organization Journal 2026 Open access

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Authors: Mounia Benbelkacem, Nabila Moulaï, Henni Chader, Eimen Kais Kadri, Lina Stamboul, Wahiba Ouahioune, Mehdi Bourouba
DOI: 10.1016/j.waojou.2026.101313
Cited by: 0
References: 2

Abstract

Oral squamous cell carcinoma (OSCC) is a highly disabling cancer characterized by chemoresistance, aggressive tumor progression, and a pro-tumoral inflammatory microenvironment. This study aimed to evaluate the therapeutic efficacy and underlying mechanisms of a triple combination therapy targeting tumor glycolytic metabolism, autophagy, and reactive oxygen species (ROS), and to investigate its impact on inflammatory and metastatic signaling pathways in a 4-nitroquinoline-1-oxide (4NQO) induced OSCC mouse model.

Fields of Study & Subjects

Cancer Hypoxia and Metabolism Head and Neck Cancer Studies Autophagy in Disease and Therapy

Publication details

Journal / source
World Allergy Organization Journal
Volume
19
Issue
2
Pages
101313–101313
Publication date
1 February 2026
Language
EN