Phylogenomics-driven metalloantibiotic engineering: Overcoming ciprofloxacin resistance in Pseudomonas aeruginosa with sideromycin-bismuth synergy

Cell Reports Medicine 2026 Open access

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Authors: Jianwei Chen, Jiangwei Pan, Xingyue Lu, Lu Wang, Keli Tan, Yujie Yue, Liting Gu, Siqi Wang, Minghong Chen, Hong Jiang, Yu Pan, Yuanquan Yu
+3 more Jianwei Nai, Dahong Zhang, Hong Wang
DOI: 10.1016/j.xcrm.2026.102637
Cited by: 1
References: 65

Abstract

coordination complex with bismuth citrate, exerting a three-pronged antibacterial mode of action: direct DNA binding to induce damage and arrest replication, suppression of KdpC synthesis to block KdpFABC-mediated potassium transport, and inhibition of ATP production. In murine models, this combination therapy exhibits potent efficacy against ciprofloxacin-resistant P. aeruginosa with a considerable safety index. Our findings highlight the potential of phylogenomics-guided metalloantibiotic engineering for overcoming drug resistance.

Fields of Study & Subjects

Bacterial Genetics and Biotechnology Origins and Evolution of Life Bacterial biofilms and quorum sensing

Publication details

Journal / source
Cell Reports Medicine
Publisher
Elsevier BV
Volume
7
Issue
3
Pages
102637–102637
Publication date
26 February 2026
Language
EN