Spleen-targeted neoantigen mRNA vaccine induces ISG15+ CD8+ T cell-mediated tertiary lymphoid structure formation in hepatocellular carcinoma

Cell Reports Medicine 2026 Open access

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Authors: Xinyi Lin, Geng Chen, Ruijing Tang, Ming Wu, Da Zhang, Fangzhou Lin, Jianhua Guan, Jing Yang, Xiuqing Dong, Xiaoyuan Zheng, Liman Qiu, Haijun Yu
+2 more Zhixiong Cai, Xiaolong Liu
DOI: 10.1016/j.xcrm.2026.102754
Cited by: 1
References: 62

Abstract

T cells and antigen-presenting cells (APCs), which is also confirmed in HCC patients. Taken together, our findings demonstrate the potent antitumor efficacy of spleen-targeted mRNA vaccine and reveal its underlying immune cell interactive mechanisms, presenting high potential for clinical translation.

Fields of Study & Subjects

interferon and immune responses Cancer Immunotherapy and Biomarkers Immunotherapy and Immune Responses

Publication details

Journal / source
Cell Reports Medicine
Publisher
Elsevier BV
Volume
7
Issue
5
Pages
102754–102754
Publication date
20 April 2026
Language
EN