Dual-system engineered bacteria and dendritic cells enable precise intratumoral IL-12 delivery and potent antitumor immunity

Cell Reports Medicine 2026 Open access

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Authors: Yuan Deng, Heng Liang, Arabella H. Wan, Chuwei Liu, Shijia Yan, Jiarui Li, Min Xiao, Qiusheng Zhou, Ruhua Liu, Zitong Zhang, 张鹤腾, Huiya Cheng
+8 more Chengyuan Fu, Qijun Yao, Juan Fang, Silke Neumann, Qiaoping Wang, Jun Huang, Zhi Wang, Guohui Wan
DOI: 10.1016/j.xcrm.2026.102801
Cited by: 1
References: 44

Abstract

T cell infiltration, and suppresses tumor growth and metastatic burden. The system also prolongs survival and remains controllable by antibiotic-mediated clearance. These findings support a programmable microbial-cellular strategy for localized cytokine delivery and immune activation in immunologically cold tumors.

Fields of Study & Subjects

Cancer Research and Treatments Immunotherapy and Immune Responses Toxin Mechanisms and Immunotoxins

Publication details

Journal / source
Cell Reports Medicine
Publisher
Elsevier BV
Volume
7
Issue
6
Pages
102801–102801
Publication date
8 May 2026
Language
EN