Circulating cell-free mtDNA fragmentomics for early detection of gastric cancer and precancerous lesions

Cell Reports Medicine 2026 Open access

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Authors: Miao Dang, Siyuan Wang, Haitao Zhang, Hengmin Xu, Linzhi Lu, Ying Liu, Yue Liu, Huanmin Jiao, Wenying Yang, Fan Peng, Xianchun Gao, Fang Lin
+8 more Ke Dong, Pan Kaifeng, R Q Lu, Renquan Lu, Yongzhan Nie, Yang Liu, Yang Liu, Jinliang Xing
DOI: 10.1016/j.xcrm.2026.102825
Cited by: 1
References: 39

Abstract

Gastric cancer (GC) requires non-invasive early detection beyond insensitive serum biomarkers and invasive endoscopy. Circulating cell-free mitochondrial DNA (ccf-mtDNA) fragmentomics offers liquid biopsy potential. Using capture-based deep sequencing in 1,951 participants across multiple centers, we develop a random forest-based GC detection (GD) model. The GD model achieves high accuracy for GC (sensitivity >90%, specificity >93%). In a nested case-control study (42 GC cases, 42 matched controls), it detects preclinical GC with time-dependent sensitivity from 62.50% (>3 years pre-diagnosis) to 85.71% (

Fields of Study & Subjects

Cancer Genomics and Diagnostics Cancer Cells and Metastasis Molecular Biology Techniques and Applications

Publication details

Journal / source
Cell Reports Medicine
Publisher
Elsevier BV
Volume
7
Issue
6
Pages
102825–102825
Publication date
20 May 2026
Language
EN