A first-principles quantitative framework for how cohesin regulators shape chromatin loop extrusion

Cell Genomics 2026 Open access

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Authors: Zibin Huang, Xinyi Liu, Junjun Ding
DOI: 10.1016/j.xgen.2026.101187
Cited by: 0
References: 10

Abstract

In this issue of Cell Genomics, Tortora and Fudenberg develop a first-principles framework in which loop extrusion is quantitatively regulated by multiple cohesin-associated factors, giving rise to "bursty extrusion." This model predicts regulator-dependent changes in motor kinetics, chromatin contact patterns, and chromosome-scale morphology across spatial scales, providing a mechanistically grounded basis for quantitative modeling of 3D genome architecture.

Fields of Study & Subjects

Genomics and Chromatin Dynamics Chromatin Remodeling and Cancer Nuclear Structure and Function

Publication details

Journal / source
Cell Genomics
Volume
6
Issue
3
Pages
101187–101187
Publication date
1 March 2026
Language
EN