A unified ACSF3-mtFAS model linking mitochondrial energy metabolism to human anthropometric evolution
Abstract
We here propose a mitochondria-centered reinterpretation of the ACSF3 regulatory variant reported by Zhang et al., integrating advances in mitochondrial fatty acid synthesis and ACSF3-deficient models to link subcellular control of oxidative efficiency with organismal traits such as basal metabolic rate, height, and systemic growth regulation in humans.
Fields of Study & Subjects
Mitochondrial Function and Pathology
Genetics
Aging
and Longevity in Model Organisms
Birth
Development
and Health
Publication details
- Journal / source
- Cell Genomics
- Publisher
- Elsevier BV
- Volume
- 6
- Issue
- 4
- Pages
- 101195–101195
- Publication date
- 1 April 2026
- Language
- EN