Transcriptome-wide association study of cardiovascular outcomes in chronic kidney disease: The chronic renal insufficiency cohort

Human Genetics and Genomics Advances 2026 Open access

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Authors: Bridget M. Lin, Jia Wen, Andrea R. V. R. Horimoto, Lingbo Zhou, Shuai Huang, Mirela A. Dobre, Alan S. Go, Yun Li, Nora Franceschini, Amanda H. Anderson, Lawrence J. Appel, Jing Chen
+8 more Debbie L. Cohen, LM Dember, Alan S. Go, James P. Lash, Mahboob U. Rahman, Panduranga S. Rao, Vallabh O. Shah, Mark L. Unruh
DOI: 10.1016/j.xhgg.2026.100562
Cited by: 1
References: 40

Abstract

). Variants near KDELR2 have been associated with coronary artery disease, which is a main cause of heart failure, while KHDRBS2 has been associated with cardiovascular risk factors in genome-wide association studies. Our findings highlight differences in gene discovery for TWAS of cardiovascular disease applied to high-risk participants based on participant ancestry and gene expression reference panels, and gains to identify genes compared with traditional genome-wide association approaches.

Fields of Study & Subjects

Genetic Associations and Epidemiology Chronic Kidney Disease and Diabetes Parathyroid Disorders and Treatments

Publication details

Journal / source
Human Genetics and Genomics Advances
Publisher
Elsevier BV
Volume
7
Issue
2
Pages
100562–100562
Publication date
8 January 2026
Language
EN